Dr. Sisi Li is a Professor at the International Cancer Center, Medical School, Shenzhen University, where she serves as a doctoral supervisor. She received her PhD from Fudan University and completed her postdoctoral training at Memorial Sloan Kettering Cancer Center in New York.

Dr. Li is a recipient of the National Young Talent Program (Category B), the Shenzhen Outstanding Youth Foundation, and the Shenzhen Overseas High-Level Talent designation. She currently serves as a council member of the Shenzhen Federation of Western-Returned Scholars and as a committee member of the Basic Medical Sciences Branch of the Chinese Society of Biochemistry and Molecular Biology.

Research

Her laboratory investigates the molecular mechanisms underlying RNA homeostasis regulation. Integrating biochemistry, molecular biology, and cell biology, the group has established a comprehensive research framework that spans:

• Chemical and structural analysis of regulatory RNAs
• Elucidation of RNA–protein regulatory mechanisms governing transcript stability and function
• In vivo validation of physiological roles in development and disease
• Exploration of RNA-targeted therapeutic strategies, with a particular focus on immune-related disorders

Publications & Recognition

Over the past five years, Dr. Li has published more than ten papers as first or corresponding author (including co-corresponding) in journals such as Science, Nature Communications, Nature Chemical Biology, PNAS, and Molecular Plant. Several of her studies have been highlighted by accompanying commentaries and featured in academic media. She serves as a reviewer for multiple internationally recognized journals and is the principal investigator of numerous national and provincial research grants from the NSFC, Shenzhen Municipal Science and Technology Innovation Commission, and other agencies.

Selected Funding

Principal Investigator

1. National Natural Science Foundation of China (NSFC) General Program, No. 32471253 (2025.01–2028.12)
2. Shenzhen Medical Research Fund, No. B2402026 (2025.01–2027.12)
3. Shenzhen Outstanding Young Investigator Program for Basic Research, No. RCJC20231211085924032 (2024.01–2029.12)
4. National Science Fund for Young Scientists Fund (B Class) (NSFC), No. 32222039 (2023.01–2025.12)
5. National Natural Science Foundation of China (NSFC) General Program, No. 31870755 (2019.01–2022.12)

Co-Investigator / Key Participant

6. First Core Member, Guangdong Innovative and Entrepreneurial Research Team Program (2017.06–2022.05)
7. First Core Member, Shenzhen Peacock Team Program (2017.06–2022.05)